Evaluation of topical administration of mucoadhesive gel containing triamcinolone and extracts of Aloe vera and propolis for surgical wound tissue repair in the tongue of rats
Tipo de material:
ArtigoAssunto(s): Recursos online:
Em: Revista Brasileira de Plantas Medicinais (Brazil) v. 24(1) p. 29-37; (2022)Sumário:
ABSTRACT
Triamcinolone acetonide (TA) is a drug used to relieve signs and symptoms of oral ulcers, which can trigger adverse effects when administered for a long period. Thus, Aloe Vera (AV) and propolis appear as therapeutic alternatives for the management of oral wounds, due to their healing properties and few side effects. This study aimed to evaluate the influence of AV and propolis on the repair of surgical wounds in the tongue of rats, and compare it with TA, through clinical and histopathological analyses. A lesion was made on the back of the tongue of 48 Wistar rats. The animals were divided into 4 groups: NCG (0.9% saline solution); PCG (TA 1 mg/g); AVG (0.5% AV); PG (5% propolis). Drugs were administered for 12/12 h. Euthanasia occurred on the 3rd and 7th days of the experiment. On day 7, AVG and PG had intermediate sized ulcers, not differing from PCG and NCG. Histological analysis showed that the reepithelialization score was significantly higher in NCG and AVG than in PCG and PG. Thus, it was demonstrated that the administration of 0.5% AV mucoadhesive gel of 12/12 h was not able to optimize the healing process of oral ulcers.
Keywords: Aloe, Propolis, Oral ulcer, Wound healing
| Tipo de material | Biblioteca atual | Coleção | Número de chamada | Informaçaõ do volume | URL | Situação | Devolução em | Código de barras |
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Periódicos
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Biblioteca Nacional de Agricultura - Binagri | Periódicos agrícolas | 2022 24(1) | Texto integral (PDF) | Consulta local | 2024-5150 |
Publicação on-line; 46 ref.; 2 tables; Summary (En)
ABSTRACT
Triamcinolone acetonide (TA) is a drug used to relieve signs and symptoms of oral ulcers, which can trigger adverse effects when administered for a long period. Thus, Aloe Vera (AV) and propolis appear as therapeutic alternatives for the management of oral wounds, due to their healing properties and few side effects. This study aimed to evaluate the influence of AV and propolis on the repair of surgical wounds in the tongue of rats, and compare it with TA, through clinical and histopathological analyses. A lesion was made on the back of the tongue of 48 Wistar rats. The animals were divided into 4 groups: NCG (0.9% saline solution); PCG (TA 1 mg/g); AVG (0.5% AV); PG (5% propolis). Drugs were administered for 12/12 h. Euthanasia occurred on the 3rd and 7th days of the experiment. On day 7, AVG and PG had intermediate sized ulcers, not differing from PCG and NCG. Histological analysis showed that the reepithelialization score was significantly higher in NCG and AVG than in PCG and PG. Thus, it was demonstrated that the administration of 0.5% AV mucoadhesive gel of 12/12 h was not able to optimize the healing process of oral ulcers.
Keywords: Aloe, Propolis, Oral ulcer, Wound healing
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