02785nab a2200277 i 4500003000900000005001700009008004100026040001800067072000800085072000800093100001700101100002600118100001700144100001700161100002300178245008200201500009400283520087600377520087101253650003002124650002102154650001802175650001102193773022402204856007902428BR-BrBNA20240628093959.0240628b2015    bl.qr|pooa||| 00| 0 por |  aBR-BrBNAbpor  aS01  aF60  aCordovil, K.  aCople-Rodrigues, C.S.  aSantos, I.N.  aFranco, E.D.  aBertolucci, S.K.V.  aRevisão das Propriedades Medicinais de Cajanus cajan na Doença Falciforme  aPublicação on-line; Bibliography p. 1205-1207 (65 ref.); 3 tables; Summaries (En, Pt)  a

RESUMO: 

Este artigo descreve a ocorrência, características botânicas, fitoquímicas e a
composição nutricional do feijão guandu [Cajanus cajan (L.) Millsp], e sua relação no processo
de inibição da falcização na doença falciforme, um distúrbio genético que acomete as hemácias,
gerando hemólise e anemia crônica. Dois constituintes químicos estariam mais relacionados aos
efeitos inibitórios na falcização de células falciformes: L-fenilalanina e o ácido p-hidroxibenzóico.
Estudos químico-biológicos detalhados com o feijão guandu no Brasil poderão esclarecer melhor
os mecanismos pelos quais ocorre a inibição da falcização das hemácias e a diminuição do
estresse oxidativo, ajudando no tratamento de pessoas com DF.

Palavras-chave: propriedades medicinais, cajanus cajan, anemia falciforme.  a

ABSTRACT: 

Review of Medicinal Cajanus cajan of properties in Sickle Cell Disease.
This article describes the occurrence, botanical characteristics, phytochemical and nutritional
composition of pigeonpea [Cajanus cajan (L.) Millsp], and their relationship in the process
inhibition of sickling in sickle cell disease (SCD), a genetic disorder that affects red blood cells,
causing hemolysis and chronic anemia. Two chemical components would be related to the
inhibitory effect on sickling of sickle cells: the L-phenylalanine and the p- hydroxybenzoic acid.
In Brazil, detailed studies with pigeonpea chemical-biological may clarify the mechanisms by
which the inhibition of sickling of red blood cells occurs, reducing oxidative stress and thus
helping treating people affected by this disease.

Keywords: medicinal properties, cajanus cajan, sickle cell anemia.  aCOMPOSIÇÃO BOTÂNICA  aPLANTA MEDICINAL  aCAJANUS CAJAN  aANEMIA0 03543dBotucatu-SP Instituto de Biociências - Departamento de Química e Bioquímica 1998o2024-2525tRevista Brasileira de Plantas Medicinais (Brazil)x1516-0572gv. 17(4 suppl. 3) p. 1199-1207; (2015)wBR2024001458  uhttps://www.scielo.br/j/rbpm/a/hyBMLMXfCknGbPQjpkmxZrg/?format=pdf&lang=pt