03375nab a2200265 i 4500003000900000005001700009008004100026040001800067072001400085072000800099100002500107100002800132100002800160100004000188245006900228500005500297520132600352520109801678650000902776650002302785650001902808650001802827773018702845856007703032BR-BrBNA20240628144043.0240628b2016    bl.mr|pooa||| 00| 0 eng |  aBR-BrBNAbeng  aL74b5500  aL70  aBento, Daniel Diola   aZahn, Fabíola Soares   aDuarte, Laura Carolina   aMachado, Luiz Henrique de Araújo   aFeline primary hyperaldosteronism: an emerging endocrine disease  aPublicação on-line; 28 ref.; Sumaries (En, Pt)  a

ABSTRACT - The primary hyperaldosteronism, an endocrine disease increasingly identified in cats, is characterized by adrenal gland dysfunction that interferes with the renin-angiotensinaldosterone system, triggering the hypersecretion of aldosterone. Pathophysiological consequences of excessive aldosterone secretion are related to increased sodium and water retention, and increased excretion of potassium, which induce hypertension and severe hypokalemia, respectively. The most common clinical findings in cats include: polydipsia, nocturia, polyuria, generalized weakness, neck ventroflexion, syncope, anorexia, weight loss, pendulous abdomen and blindness. Diagnosis is based on the evidence of hormonal hypersecretion with suppression of renin release, imaging and histopathological evaluation of adrenal glands. Treatment may be curative with adrenalectomy, in cases of unilateral disease, or conservative, through administration of aldosterone antagonists, potassium supplementation and antihypertensives. Prognosis varies from fair to good with the appropriate therapy. This article reviews the main aspects of primary aldosteronism in cats, providing the clinician with important information for the diagnosis of this disease.

Key words: feline medicine, endocrinology, adrenocortical disease, hypertension.  a

RESUMO - O hiperaldosteronismo primário, doença endrócrina cada vez mais identificada em felinos, caracteriza-se pela disfunção da glândula adrenal com interferência no sistema reninaangiotensina-aldosterona, desencadeando a hipersecreção de aldosterona. As consequências da secreção excessiva de aldosterona estão relacionadas com o aumento da retenção de sódio e água e aumento da excreção de potássio, que ocasionarão, respectivamente, hipertensão arterial sistêmica e hipocalemia grave. O diagnóstico é realizado com base na comprovação da hipersecreção hormonal com supressão da liberação de renina, além de exames de imagem e avaliação histopatológica da adrenal. O tratamento pode ser curativo, com a adrenalectomia, em enfermidades unilaterais, ou conservativo, por meio de antagonistas da aldosterona, suplementação de potássio e anti-hipertensivos. O prognóstico é bom e reservado com a terapia apropriada.

Palavras-chave: medicina felina, endocrinologia, enfermidade adrenocortical, hipertensão.  aGATO  aDISTÚRBIO ANIMAL  aENDOCRINOLOGIA  aVETERINÁRIA0 02408dSanta Maria-RS Universidade Federal de Santa Maria - Centro de Ciências Rurais 1991o2024-1177tCiência Rural (Brazil)x0103-8478gv. 46(4) p. 686-693; (2016)wBR2024001282  uhttps://www.scielo.br/j/cr/a/M5fNNbRm68Z99DTNrQ5BX6P/?format=pdf&lang=en