02552nab a2200349 i 4500 BR-BrBNA 20240927132018.0 240927b2022 bl.qr|pooa||| 00| 0 eng | BR-BrBNA eng Q01 D50 S01 F50 F60 Pangoni, Fernanda Belincanta Borghi Souza, Bruna Gheller de Previato, Wilson Nathan de Carvalho Yau, Marcos Albiero, Adriana Lenita Meyer Diniz, Andrea Do Crataegus pinnatifida capsules sold in Brazil undergo pharmaceutical quality control? Is there a quality control adopted in Brazil? Publicação on-line; 28 ref.; 2 illus.; Summary (En) ABSTRACT The Chinese hawthorn, Crataegus pinnatifida, Rosaceae, is widely used in Traditional Chinese Medicine (TCM). As there is no Brazilian legislation to carry out the quality evaluation of this drug, this work aimed to carry out the quality control of C. pinnatifida capsules (Shan Zha), sold commercially in Brazil. Due to lack of reference standard, an extract of the C. pinnatifida fruits (EC) was prepared. The quality control of the fruits presented adequate botanical analysis of the fruits and presented macroscopic characteristics in accordance with Chinese Pharmacopoeia. For the fruits, the sample had no foreign matter and the total ash content was 0.724 ± 0.160%. The capsules showed adequate dose uniformity, moisture content of 14.75 ± 0.476%, total ash content of 1.51 ± 0.199%. The total flavonoid (TF) percentage was 0.012% for the dried extract of fruits and 0.005% for the Shan Zha capsules. This study highlights the importance of carrying out quality control to ensure the authenticity and quality of products that fall within the classification of supplements in Brazilian legislation and guide the dose calculation for C. pinnatifida products. Keywords: Thin layer chromatography, phytopharmaceutical products, total phenolic content. CROMATOGRAFIA FENOL CONTROLE DE QUALIDADE PLANTA MEDICINAL 3543 344879 Botucatu-SP Instituto de Biociências - Departamento de Química e Bioquímica 1998 2024-5207 Revista Brasileira de Plantas Medicinais (Brazil) 1516-0572 v. 24(2) p. 73-80; (2022) BR2024002603 https://www.sbpmed.org.br/admin/files/papers/file_9v4omqCdCGmF.pdf ANA 327856 327856