02514nab a2200337 i 4500003000900000005001700009008004100026040001800067072000800085072000800093072000800101072000800109072000800117100004100125100002900166100004100195100001700236100003500253100001900288245014000307500006000447520127700507650001801784650001001802650002601812650002101838773021901859856007102078942000802149999001902157BR-BrBNA20240927132018.0240927b2022    bl.qr|pooa||| 00| 0 eng |  aBR-BrBNAbeng  aQ01  aD50  aS01  aF50  aF60  aPangoni, Fernanda Belincanta Borghi   aSouza, Bruna Gheller de   aPreviato, Wilson Nathan de Carvalho   aYau, Marcos   aAlbiero, Adriana Lenita Meyer   aDiniz, Andrea   aDo Crataegus pinnatifida capsules sold in Brazil undergo pharmaceutical quality control? Is there a quality control adopted in Brazil?   aPublicação on-line; 28 ref.; 2 illus.; Summary (En)  a

ABSTRACT 

The Chinese hawthorn, Crataegus pinnatifida, Rosaceae, is widely used in Traditional Chinese Medicine (TCM). As there is no Brazilian legislation to carry out the quality evaluation of this drug, this work aimed to carry out the quality control of C. pinnatifida capsules (Shan Zha), sold commercially in Brazil. Due to lack of reference standard, an extract of the C. pinnatifida fruits (EC) was prepared. The quality control of the fruits presented adequate botanical analysis of the fruits and presented macroscopic characteristics in accordance with Chinese Pharmacopoeia. For the fruits, the sample had no foreign matter and the total ash content was 0.724 ± 0.160%. The capsules showed adequate dose uniformity, moisture content of 14.75 ± 0.476%, total ash content of 1.51 ± 0.199%. The total flavonoid (TF) percentage was 0.012% for the dried extract of fruits and 0.005% for the Shan Zha capsules. This study highlights the importance of carrying out quality control to ensure the authenticity and quality of products that fall within the classification of supplements in Brazilian legislation and guide the dose calculation for C. pinnatifida products. 

Keywords: Thin layer chromatography, phytopharmaceutical products, total phenolic content.
  aCROMATOGRAFIA  aFENOL  aCONTROLE DE QUALIDADE  aPLANTA MEDICINAL0 035439344879dBotucatu-SP Instituto de Biociências - Departamento de Química e Bioquímica 1998o2024-5207tRevista Brasileira de Plantas Medicinais (Brazil)x1516-0572gv. 24(2) p. 73-80; (2022)wBR2024002603  uhttps://www.sbpmed.org.br/admin/files/papers/file_9v4omqCdCGmF.pdf  cANA  c327856d327856