000			02522nab a2200325 i 4500
003			BR-BrBNA
005			20240927112358.0
008			240927b2022 bl.qr|pooa||| 00| 0 eng |
040			_aBR-BrBNA _beng
072			_aF60
072			_aS01
100			_aJulião, Erielma Lomba Dias
100			_aAzevedo, Juliana Santos de Jesus
100			_aSousa, Fábio Luís Menezes de
100			_aMedrado, Alena Ribeiro Alves Peixoto
100			_aDantas, Juliana Borges de Lima
100			_aNéri, Júlia dos Santos Vianna
245			_aEvaluation of topical administration of mucoadhesive gel containing triamcinolone and extracts of Aloe vera and propolis for surgical wound tissue repair in the tongue of rats
500			_aPublicação on-line; 46 ref.; 2 tables; Summary (En)
520			_a ABSTRACT Triamcinolone acetonide (TA) is a drug used to relieve signs and symptoms of oral ulcers, which can trigger adverse effects when administered for a long period. Thus, Aloe Vera (AV) and propolis appear as therapeutic alternatives for the management of oral wounds, due to their healing properties and few side effects. This study aimed to evaluate the influence of AV and propolis on the repair of surgical wounds in the tongue of rats, and compare it with TA, through clinical and histopathological analyses. A lesion was made on the back of the tongue of 48 Wistar rats. The animals were divided into 4 groups: NCG (0.9% saline solution); PCG (TA 1 mg/g); AVG (0.5% AV); PG (5% propolis). Drugs were administered for 12/12 h. Euthanasia occurred on the 3rd and 7th days of the experiment. On day 7, AVG and PG had intermediate sized ulcers, not differing from PCG and NCG. Histological analysis showed that the reepithelialization score was significantly higher in NCG and AVG than in PCG and PG. Thus, it was demonstrated that the administration of 0.5% AV mucoadhesive gel of 12/12 h was not able to optimize the healing process of oral ulcers. Keywords: Aloe, Propolis, Oral ulcer, Wound healing
650			_aALOE VERA
650			_aPRÓPOLIS
650			_aÚLCERA
650			_aCICATRIZAÇÃO
650			_aLESÃO
773	0		_03543 _9344822 _dBotucatu-SP Instituto de Biociências - Departamento de Química e Bioquímica 1998 _o2024-5150 _tRevista Brasileira de Plantas Medicinais (Brazil) _x1516-0572 _gv. 24(1) p. 29-37; (2022) _wBR2024002595
856			_uhttps://www.sbpmed.org.br/admin/files/papers/file_ebDK2dNgW5DR.pdf
942			_cANA
999			_c327849 _d327849