000			02552nab a2200349 i 4500
003			BR-BrBNA
005			20240927132018.0
008			240927b2022 bl.qr|pooa||| 00| 0 eng |
040			_aBR-BrBNA _beng
072			_aQ01
072			_aD50
072			_aS01
072			_aF50
072			_aF60
100			_aPangoni, Fernanda Belincanta Borghi
100			_aSouza, Bruna Gheller de
100			_aPreviato, Wilson Nathan de Carvalho
100			_aYau, Marcos
100			_aAlbiero, Adriana Lenita Meyer
100			_aDiniz, Andrea
245			_aDo Crataegus pinnatifida capsules sold in Brazil undergo pharmaceutical quality control? Is there a quality control adopted in Brazil?
500			_aPublicação on-line; 28 ref.; 2 illus.; Summary (En)
520			_a ABSTRACT The Chinese hawthorn, Crataegus pinnatifida, Rosaceae, is widely used in Traditional Chinese Medicine (TCM). As there is no Brazilian legislation to carry out the quality evaluation of this drug, this work aimed to carry out the quality control of C. pinnatifida capsules (Shan Zha), sold commercially in Brazil. Due to lack of reference standard, an extract of the C. pinnatifida fruits (EC) was prepared. The quality control of the fruits presented adequate botanical analysis of the fruits and presented macroscopic characteristics in accordance with Chinese Pharmacopoeia. For the fruits, the sample had no foreign matter and the total ash content was 0.724 ± 0.160%. The capsules showed adequate dose uniformity, moisture content of 14.75 ± 0.476%, total ash content of 1.51 ± 0.199%. The total flavonoid (TF) percentage was 0.012% for the dried extract of fruits and 0.005% for the Shan Zha capsules. This study highlights the importance of carrying out quality control to ensure the authenticity and quality of products that fall within the classification of supplements in Brazilian legislation and guide the dose calculation for C. pinnatifida products. Keywords: Thin layer chromatography, phytopharmaceutical products, total phenolic content.
650			_aCROMATOGRAFIA
650			_aFENOL
650			_aCONTROLE DE QUALIDADE
650			_aPLANTA MEDICINAL
773	0		_03543 _9344879 _dBotucatu-SP Instituto de Biociências - Departamento de Química e Bioquímica 1998 _o2024-5207 _tRevista Brasileira de Plantas Medicinais (Brazil) _x1516-0572 _gv. 24(2) p. 73-80; (2022) _wBR2024002603
856			_uhttps://www.sbpmed.org.br/admin/files/papers/file_9v4omqCdCGmF.pdf
942			_cANA
999			_c327856 _d327856