000			02419nab a2200289 i 4500
003			BR-BrBNA
005			20250130115911.0
008			250130b2016 bl.|r|pooa||| 00| 0 por |
040			_aBR-BrBNA _bpor
072			_aL70 _b8830
100			_aOliveira, S.S.
100			_aLopes, L.L.
100			_aDamazo, A.S.
100			_aAlbuquerque, D.
245			_aEnalapril e captopril revertem o edema e a hiperplasia renais causados pelo antimoniato de N-metilglucamina em camundongos C57BL/6
500			_a Publicação online; 11 ref.; Summary (En)
520			_a ABSTRACT - The aim of this study was to verify whether enalapril and captopril would reverse the renal damage caused by N-methylglucamine antimoniate in C57BL/6 mice. We used inbred C57BL/6 female mice, obtained from the Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BA. The mice were divided into four groups as follows: Group1: received saline by the intramuscular (IM) route; Group 2: received Nmethylglucamine antimonate (IM); Group 3: received N-methylglucamine antimoniate and captopril; Group 4: was treated with N-methylglucamine antimoniate and enalapril. Both enalapril and captopril were orally administered in drinking water (ad libitum). After 30 days of treatment, the animals were sacrificed and their kidneys were collected for histological analysis which showed that enalapril completely reversed the edema, the podocytes hyperplasia and nucleus of the epithelial cells in the proximal convoluted tubules caused by N-methylglucamine antimoniate. On the other hand, the captopril treatment partially inhibited kidney harmful effects caused by N-metilgucamina antimoniate. Taken together, we would conclude that enalapril and captopril reverse edema and renalhyperplasia caused by N-methylglucamine antimonate in mice. Keywords: enzyme-converting inhibitors, glucantime, renototoxicidade
650			_aCAMUNDONGO
650			_aANIMAL DE LABORATÓRIO
650			_aMEDICAMENTO
650			_aRIM
650			_aVETERINÁRIA
773	0		_01643 _9348075 _dBelo Horizonte-MG Universidade Federal de Minas Gerais - Escola de Veterinaria 1983 _o2025-0570 _tArquivo Brasileiro de Medicina Veterinária e Zootecnia (Brazil) _x0102-0935 _gv. 68(4) p. 1095-1098; (2016) _wBR2024004619
856			_uhttps://www.scielo.br/j/abmvz/a/wwVxMLL9fD455zgfJpGxjzy/?format=pdf&lang=pt
942			_cANA
999			_c329744 _d329744