000			03252nab a2200361 i 4500
003			BR-BrBNA
005			20250410202925.0
008			250410b2020 bl.ar|pooa||| 00| 0 eng |
040			_aBR-BrBNA _beng
072			_aL51 _b6100
072			_aL50
100			_aKreuz, Bruna Strieder
100			_aRocha, Gabriel Cipriano
100			_aCampos, Paulo Henrique Reis Furtado
100			_aSilva, Fabyano Fonseca e
100			_aHannas, Melissa Izabel
100			_aAlbino, Luiz Fernando Teixeira
100			_aBorges, Samuel Oliveira
100			_aCalderano, Arele Arlindo
245			_aEffects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge
500			_aPublicação on-line; 37 ref.; 4 tables; Sumaries (En)
520			_a ABSTRACT - The objective of this study was to evaluate the effects of dietary nucleotide supplementation on growth performance, serum immunoglobulin G (IgG) and uric acid levels, immune-related organs, and intestinal morphometric parameters of broiler chickens under pre- and post-inflammatory challenge with lipopolysaccharide (LPS). Ninety-six seven-day-old male broiler chicks were randomized in a 2×2 factorial design composed of two dietary types (supplemented with 0 and 0.3 g of purified nucleotides/kg of feed) and two inflammatory conditions (with and without LPS administration) with eight replicates per treatment and three birds per cage. The experimental period was divided into two phases: 7-20 days of age (pre-LPS challenge) and 21-35 days of age (post-LPS challenge). Data were analyzed using one-way and two-way ANOVA for the pre- and post-challenge phases, respectively. During the prechallenge phase, dietary nucleotide supplementation improved body weight (982 vs. 1009 g/bird), daily weight gain (58.1 vs. 60.1 g/bird), feed conversion rate (1.28 vs. 1.25 g/g), and serum concentration of IgG (1.17 vs. 1.76 mg/mL) of broilers. During the post-challenge phase, nucleotide supplementation increased serum IgG of broilers at 28 days of age (3.01 vs. 4.34 mg/mL). For the intestinal morphometric parameters, nucleotide supplementation increased villus height (299.3 vs. 315.6 μm). Dietary nucleotide supplementation improves the performance of broilers from seven to 20 days of age (pre-LPS challenge). However, from 21 to 35 days of age, supplementation of 0.3 g of purified nucleotides/kg of feed, independent of inflammatory challenge, does not contribute to improve performance of broilers. Additionally, nucleotide supplementation increases IgG production and villus height in the jejunum of broilers. Keywords: immunoglobulin, feed additive, nutrition, poultry
650			_aFRANGO DE CORTE
650			_aDIETA
650			_aSUPLEMENTO ALIMENTAR
650			_aIMUNOGLOBULINA
650			_aANÁLISE QUÍMICA
650			_aCONVERSÃO ALIMENTAR
773	0		_03545 _9317600 _dViçosa-MG Sociedade Brasileira de Zootecnia 1997 _o2024-4310 _tRevista Brasileira de Zootecnia (Brazil) _x1516-3598 _gv. 49 p. 1-10; (2020) _wBR2025000564
856			_uhttps://www.scielo.br/j/rbz/a/qNGXq43TgMNQnzKJx7v4Pzw/?format=pdf&lang=en
942			_cANA
999			_c330979 _d330979